Make a donation. Ask your provider for resources to, Limit alcohol intake, and avoid it during long flights (it can lead to, Move around more. xref All rights reserved. You won't go hungry on The 5-Factor Diet. New York, N.Y.: McGraw-Hill Education; 2016. https://accessmedicine.mhmedical.com. If youve been diagnosed with DVT or a PE, youll have frequent follow-up appointments so your provider can check treatment progress. Healthy fat (from fish such as salmon, tuna, mackerel, sardines, rainbow trout, or peanut oil, olive oil, canola oil, sunflower oil, Sugar-free drinks (water, sugar-free soda, coffee, tea, or an unsweetened energy drink). There are 2 copies for Factor V gene, which are passed down from our parents. You probably wont know you have prothrombin gene mutation unless you have a specific blood test if/after you develop a deep vein thrombosis or pulmonary embolism. advice, care, or treatment. It is advised that vitamin K intake through diet (chiefly through liver meats, high amounts of green leafy vegetables, and cranberry juice) also be closely monitored in such patients for the same reason. Factor V Leiden is a mutation of the genes that causes impairment to the normal process of blood clotting. Low-salt, low-fat: The plan is already geared toward low-fat and low-salt foods and may be adjusted further if needed. Farshchi, H. American Journal of Clinical Nutrition, January 2005. The Factor V Leiden protein is harder to turn off than the normal Factor V protein. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. If you or a loved one have factor V Leiden, you might feel scared about what the future will bring. However, there are things that you can do to reduce your chances of developing a dangerous blood clot. It is important to note that alcohol also has some anticoagulant action and can protect adults from blood clots, although it is not recommended as a preventative measure for this purpose. This content does not have an Arabic version. There is also a 50% chance that your child will inherit your normal Factor V gene. Your child will have either the heterozygous or homozygous type, depending on whether the gene passed down from his or her other parent is normal (Factor V) or abnormal (Factor V Leiden). Philadelphia, PA 19182-5687. Most people with factor V Leiden never develop abnormal clots. In a worst-case scenario, it lands in your legs, leading to deep vein thrombosis, or your lungs, forming a pulmonary embolism. Effective measures to eliminate or reduce other risk factors for DVT or PE, such as smoking cessation, weight loss and having a more active lifestyle. Here's what foods they have in common, and how to build a healthy diet when you have factor V Leiden: Advertisement 1. Individuals who happen to know that they have factor V Leiden but have never had blood clots dont have to be prescribed any blood thinners. In: Williams Hematology. Barbara Woodward Lips Patient Education Center. Learn to recognize the signs of a blood clot so that you can get help as soon as possible. However, it is often advised to avoid foods high in Vitamin K. Below is a list of foods that should be avoided because of their . Factor V Leiden thrombophilia. On a long flight, take regular walks down the aisles of the plane. In most people, a protein called activated protein C regulates the activity of . If you have symptoms of a pulmonary embolism, you should go to the closest emergency room. 0 You should either contact your provider or go to the nearest Emergency Room if you think youre having a deep vein thrombosis. Here's some information to help you prepare for your appointment. If you have factor V Leiden, there are other ways you can help reduce your risk of developing a blood clot beyond your diet. Low Vitamin K consumption if on Coumadin/Warfarin. Kaushansky K, et al., eds. About 1 out of 10,000 people will develop a DVT or PE each year. Miscarriages associated with factor V Leiden are more likely to occur later in pregnancy (after the first trimester). You do need treatment with blood thinners if you have had a blood clot or develop one in the future. Mayo Clinic is a not-for-profit organization. Its important to talk to your provider about any concerns you have related to life expectancy or future complications. Bauer KA. Zoppi, Lois. More info. Yes, those living with factor v Leiden should avoid any foods that contain a high level of vitamin K. (Green leafy vegetables are a big one). 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, (https://pubmed.ncbi.nlm.nih.gov/31577252/), (https://www.stoptheclot.org/factor-v-leiden/). If I have children, do they need to be tested? 0000001564 00000 n Accessed June 4, 2018. Mayo Clinic, Rochester, Minn. June 17, 2018. As a result, your blood may clot more easily than it should, leading to serious complications. This will help to avoid miscarriage or pregnancy complications for the following reasons: . Anticoagulants and vitamin K interactions, Anticoagulants and herbal supplement and vitamin interactions, No benefit of low dose apixaban following acute COVID-19, Study finds fractionation of sulfated galactan from red alga can isolate its anti-SARS-CoV-2 properties, Meta-analysis finds intensified anticoagulation had no effect on short term mortality among hospitalized COVID-19 patients. Exercise regularly for good circulation in the veins of your legs. But you should talk to your provider about what you can expect in your individual situation. As a result, factor V works in overdrive, making your blood more likely to clot when it shouldnt. Lose weight (if you have overweight/obesity). Can the results of the test affect my ability to obtain health insurance? Most people with this disorder never develop a blood clot. In general, its more common among people who are white in the U.S. and Europe. People with this condition have a factor V Leiden mutation, meaning theres a change in their coagulation factor V (F5) gene. Because factor V Leiden is a blood clotting condition, you need to have a discussion with your health care team about your dietary restrictions if you are on a blood-thinning medication like warfarin. https://rarediseases.info.nih.gov/diseases/6403/factor-v-leiden-thrombophilia. Have had clots two or more different times in the past. Factor V is a protein that is needed for blood to clot properly. Swelling in your leg or arm, which may appear suddenly. This gene carries instructions that tell your body how to properly create the factor V protein. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Lockwood CJ, et al. Deep vein thrombosis and pulmonary embolism. Interactions which affect the efficacy of VKAs may result in bleeding from over-anticoagulation, or thrombosis due to under-anticoagulation. Wear compression stockings if your provider prescribes them for you. These medications (called anticoagulants) help to prevent clotting. Kaushansky K, et al., eds. 0000001362 00000 n Factor V that becomes impaired can cause numerous issues with the health of the human blood. It does not increase the risk of myocardial infarction (heart attacks) or arterial strokes. Other things can add to your blood clot risk, including: Youll need a specific blood test to check for the prothrombin gene mutation. 0000022790 00000 n Factor V Leiden is the most common one. Vegetarians and vegans: You can easily modify the 5-Factor Diet for vegetarian and vegan diets, though the protein sources for vegans are somewhat limited. The sooner you receive care, the better your chances of a good outcome. Factor V Leiden (pronounced factor five) is the most common hereditary clotting disorder in the United States, present in 2 percent to 7 percent of Caucasians, less often in Hispanics and. Before using birth control pills or hormone therapy for menopause. What can I do to help prevent blood clots from forming? Youll have the prothrombin gene mutation for life, since its part of your genetic makeup. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017. Just by eliminating junk food, simple carbs, and high-calorie drinks, as in the 5-Factor Diet, most people are likely to see a dip on the scale. Avoid foods high in vitamin k (leafy greens mostly), certain supplements, and avoid consuming too much alcohol. About 1 of every 250 Black people in America has the prothrombin gene mutation. Study Results Demonstrate VTE Treatment Satisfaction Among Patients, Managing Anticoagulants Before, During, and After Medical Procedures, Helping Women Make Choices About Contraception Following DVT Blood Clots, Panel Discussion: Blood Clots & Womens Health, Frequently Asked Questions: COVID-19 and Blood Clotting, Stop the Clot, Spread the Word Hospitalization, Toolkit for Knee and Hip Replacement Patients, Health Disparities and the VTE Mississippi Initiative, Atrial Fibrillation (AFib) and Clot-Provoked Stroke, Questions to Ask Your Doctor After Having a Blood Clot, NBCA Atrial Fibrillation Awareness Survey, Impact of Blood Clots in the Black Community Research Opportunities, NBCA Sports & Wellness Institute: Team Stop the Clot, Council of Emerging Researchers in Thrombosis (CERT), Medical & Scientific Advisory Board (MASAB), not enough clotting power leads to bleeding problems, too much clotting power can lead to the formation of dangerous blood clots. According to NutritionData, the best sources of folate per 100 g serving are: Beans and lentils (~50% RDI) Raw spinach (49% RDI) Asparagus (37% RDI) Romaine (Cos) lettuce (34% RDI) Broccoli (27% RDI) Avocado (20% RDI) Oranges/Mangoes (~10% RDI) At least 1 of the genes that you inherited is the mutated gene that makes the Factor V Leiden protein. Medications can also work differently if they are taken on an empty stomach. The following supplements are theoretically capable of inhibiting VKAs, but their clinical effect is insignificant: Studies have shown that there is a 58% higher likelihood of achieving PT-INR values in the optimal therapeutic range of 2.0 to 3.0 if patients on VKA medication avoid herbal supplements or take them three or fewer times a week. How does prothrombin gene mutation affect my body? Factor V Leiden may lead to deep vein thrombosis or a pulmonary embolism, which are serious medical emergencies. They are prescribed to avoid the development of harmful blood clots. Factor V Leiden makes you more likely to develop: Its important to know that people with factor V Leiden wont necessarily develop DVT or PE. Most people with factor V Leiden never develop abnormal clots. What will a positive or negative result tell me? DVT or a PE during or shortly following pregnancy. They may also suspect it if one or more of your biological family members have a history of blood clots. The NATIONAL BLOOD CLOT ALLIANCE works to advance #bloodclot awareness, prevention, diagnosis, & successful treatments to #stoptheclot. Does It Allow for Dietary Restrictions or Preferences? Advertising on our site helps support our mission. Check with your doctor or dietitian first. Last reviewed by a Cleveland Clinic medical professional on 10/04/2022. The factor V Leiden mutation itself doesnt have any specific treatment. Researchers have found that the factor V Leiden mutation involves one small change in the proteins structure. Cleveland Clinic is a non-profit academic medical center. Do I need to take medication to prevent additional blood clots? (https://pubmed.ncbi.nlm.nih.gov/34540419/), (https://www.genome.gov/Genetic-Disorders/Factor-V-Leiden-Thrombophilia), (https://medlineplus.gov/lab-tests/coagulation-factor-tests/), (https://medlineplus.gov/genetics/gene/f5/), Visitation, mask requirements and COVID-19 information, Heart, Vascular & Thoracic Institute (Miller Family). .wpcdt-timer-24806 .wpcdt-clock .wpcdt-digits span{color: #ffffff;}.wpcdt-timer-24806 .wpcdt-clock{max-width: 640px;}, Carol McIntosh of Caroga Lake, New York was 32 when she was diagnosed with her first incident of deep vein, March is Blood Clot Awareness Month (BCAM), a time dedicated to spreading the word about blood clots and their potentially. Toll Free: 877.4.NO CLOT, National Blood Clot Alliance The weight loss and increased activity that The 5-Factor Diet promises are key to the prevention and treatment of many conditions, including heart disease, high blood pressure, and diabetes. Fortunately, about 95 percent of people with this condition never develop a clot, according to the National Institutes of Health. The need (or not) to wear graded elastic compression stockings during long-haul flights and long road trips. It even tells you what staples to keep on hand so you will always be able to get a quick meal together. Having 2 Factor V Leiden genes (homozygous type) makes the risk much greater . Diets ideal for this include the Mediterranean diet and the DASH diet. Pasternak, H. The 5-Factor Diet, Ballantine Books, 2009. diabetes.org: "Glycemic Index and Diabetes. Inherited thrombophilias in pregnancy. Vitamin K is a necessary element in the blood clotting process. New York, N.Y.: McGraw-Hill Education; 2016. https://accessmedicine.mhmedical.com. Drink plenty of fluids (without alcohol). Clots can form in the veins near your bones that carry a lot of blood (deep veins), a condition called deep vein thrombosis. 0000001706 00000 n Exercise: Required. We use cookies to enhance your experience. Factor V is a protein that is needed for blood to clot properly. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. Often, those treatments will require hospitalization. Factor V is a protein or clotting factor that helps create the enzyme reactions that form the fibrin in the clot. Going on a long flight or a very long road trip. With Factor V Leiden the risk of a blood clot increases with age 0 100 200 300 400 500 600 700 800 900 1000 Risk per 100,000 people Childhood 20's 40's 80's Having 1 Factor V Leiden gene (heterozygous type) slightly increases the chance of developing a blood clot. News-Medical. During long car rides, stop every few hours and take a short walk. Youll prepare and eat five, 5-ingredient meals a day (each takes 5 minutes to prepare) and do 25-minute workouts (consisting of five, 5-minute segments) five times a week. Inheriting two copies one from each parent significantly increases your risk of developing blood clots. Each 5-Factor five-ingredient meal must include all five must-have food groups: The 5-Factor Diet doesnt mention alcohol specifically, but on the diets cheat day you may eat or drink anything you like. Get useful, helpful and relevant health + wellness information. Blood clots can cause serious problems in your body when they block blood flow, keeping oxygen from getting to your cells. National Heart, Lung, and Blood Institute. Cooking and shopping: Youll spend minimal time and effort on cooking if you stock your refrigerator and pantry with Pasternaks top picks for 5-Factor foods. Get useful, helpful and relevant health + wellness information. Though scientific research on The 5-Factor Diet is lacking, the plan uses sound nutrition principles of healthy eating and weight loss. But in people who do, these abnormal clots can lead to long-term health problems or become life-threatening. Talk to your provider to see if you should be taking a blood thinner. Medicines help treat and prevent blood clots in people who are high risk for them. .wpcdt-timer-24806 .wpcdt-clock .wpcdt-lbl{color: #ffffff;}.wpcdt-timer-24806 .wpcdt-clock-circle span, If you have never had a blood clot, you do not need treatment with blood thinners. Your doctor may suspect factor V Leiden if you've had one or more episodes of abnormal blood clotting or if you have a strong family history of abnormal blood clots. Symptoms may resolve within days or months, depending on the location and severity of your deep vein thrombosis or pulmonary embolism. Hereditary thrombophilia. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. If you have this gene mutation, factor V is slow to turn off, and this can create a larger-than-needed clot, which could break off and start traveling through your body. Factor V Leiden and prothrombin gene mutations cause about 50% of inherited coagulopathies. 2. If you are already taking an anticoagulant, make sure you keep regular appointments with your provider. Anticoagulants, commonly called blood thinners, are a group of medications that impede the blood clotting process. Please note that medical information found Exercise regularly, such as walking, swimming or riding a bike 3 times a week. 0000003297 00000 n 76 28 Alcohol interacts with a large number of medications. We do not endorse non-Cleveland Clinic products or services. This site complies with the HONcode standard for trustworthy health information: verify here. Phone: 703.935.8845 If you do, another blood test that examines your genes (called DNA) will be done to find out if Factor V Leiden is the cause of the resistance and what type of Factor V Leiden you have. You should know the warning signs of a problematic blood clot so you can identify it and get help. Do you recommend genetic testing for any of my family members? Mango and St. Johns wort are also clinically relevant inhibitors of VKAs. News-Medical.Net provides this medical information service in accordance Accessed June 4, 2018. . %PDF-1.5 % You may have a higher risk of getting: Pulmonary embolism. https://www.news-medical.net/health/Anticoagulant-Food-Drug-Interactions.aspx. Vitamin K is found in the following foods: Liver meat Broccoli Brussels sprouts Cabbage Cheese Collard greens Kale Lentils Flaxseed Lettuce Spinach Soybean oil Turnip greens Camomile Green tea. Factor V Leiden doesnt affect life expectancy in most people. 0000007474 00000 n National Library of Medicines list Zoppi, Lois. It may ease your mind to know that most people with this disorder never have a blood clot. Middeldorp S, Coppens M. Hereditary Thrombophilia. 5. https://www.nhlbi.nih.gov/health-topics/venous-thromboembolism. Factor V Leiden is the most common one. It increases the chances that your blood will form abnormal blood clots that can be dangerous. You can have a family history of deep vein thrombosis (DVT) or pulmonary embolism (PE) but never develop either yourself. Current management strategies involve the use of pharmacotherapy, when indicated, in the event of deep venous thrombosis or pulmonary embolism. Food choices are varied enough that you can have a balanced diet and not get bored of foods. An INR value of 1.1 or below is considered normal in healthy patients, with lower values indicating faster clotting, while higher values show slower clotting rate. .wpcdt-timer-24806 {background-color: #aaaaaa;}.wpcdt-timer-24806 .wpcdt-title, .wpcdt-timer-24806 .wpcdt-desc, .wpcdt-timer-24806 .wpcdt-desc p{color: #b81d32;}.wpcdt-timer-24806 .wpcdt-clock-circle h4, Up to 1 in 50 people who are Black, Hispanic or Native American. This content does not have an English version. People who have inherited factor V Leiden from only one parent have a 5 percent chance of developing an abnormal blood clot by age 65. Here's what foods they have in common, and how to build a healthy diet when you have factor V Leiden: 1. Accessed June 4, 2018. She graduated from the University of Sussex with a BA in Media Practice, having specialized in screenwriting. Genetic and Rare Disease Information Center. They are used to treat conditions such as embolic ischemic stroke, deep vein thrombosis, and pulmonary embolism. We inherit one gene from our mother and one from our father. There is no specific treatment for the mutation itself. Eat well. The heart-healthy Mediterranean diet which includes lots of fruits and vegetables along with healthy fats is a smart choice for those with factor V Leiden. If you inherited 2 Factor V Leiden genes, you have the homozygous type of Factor V Leiden. News-Medical, viewed 04 March 2023, https://www.news-medical.net/health/Anticoagulant-Food-Drug-Interactions.aspx. Accessed June 4, 2018. Some people only need treatment for three months, but others will need blood thinner treatment indefinitely. Pruthi RK (expert opinion). These precautions might include: Some precautions to help reduce your risk of blood clots include: If your factor V Leiden requires you to take anticoagulant medication, here are some steps that might help you prevent injury and avoid excessive bleeding: Your doctor may refer you to a specialist in genetic disorders (geneticist) or a specialist in blood disorders (hematologist) for testing to determine whether the cause of your blood clots is genetic and, specifically, whether you have factor V Leiden. This helps keep the blood flowing in your legs. A single copy of these materials may be reprinted for noncommercial personal use only. Where's the Health Benefit? Most people who inherit it never develop abnormal blood clots, and may never even know they have the disorder. But not everyone with the prothrombin gene mutation and a history of deep vein thrombosis or pulmonary embolism needs blood thinners during pregnancy. Calorie counting is not a feature of this diet plan. This happens because your body makes more of the Factor II (prothrombin) protein than you need for normal clot formation. A blood test (called a screening test) can show if you have Activated Protein C resistance. Medications to treat this condition may require dietary restrictions. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. The latest information about heart & vascular disorders, treatments, tests and prevention from the No. Since then I was also diagnosed w My name is MARTIN R. LEMIEUX, and for over 20 years now Ive survived five DVTS BLOOD CLOTS in my left leg, one clot in my right leg, and another clot in my left pelvic area. As a result, too much blood clotting can happen. Women who carry the factor V Leiden mutation may have an increased tendency to develop blood clots during pregnancy or when taking the hormone estrogen. Is this an emergency? 0000006951 00000 n Will Eating More Protein Help Your Body Gain Muscle Faster? WebMD does not provide medical advice, diagnosis or treatment. Symptoms of a deep vein thrombosis or pulmonary embolism typically start getting better soon after specific treatment is started. This site complies with the HONcode standard for trustworthy health information: verify here. Pruthi RK (expert opinion). Why? But if you do, prompt treatment can manage your condition. Usually, once the clot is formed, factor V is "turned off," but not in those with factor V Leiden. If you are overweight or obese, consider the benefits of losing weight. Keep going to your follow-up appointments with your provider, especially if youre taking a blood thinner. On the other hand, chronic alcohol consumption reduces the INR. Factor V and other proteins work together to help your blood clot when necessary. NBCA provides the information and materials on this site for general information purposes only. Cleveland Clinic is a non-profit academic medical center. Factor V Leiden is an inherited blood clotting disorder that raises your risk of deep vein thrombosis or a pulmonary embolism. It is not associated with an increase risk of cancer or birth defects. Accessed June 4, 2018. The American Heart Association cites the following as risk factors for blood clots: 5 Symptoms of a Blood Clot You Should Know. <]>> you have a medical emergency, call 911 immediately. The mutation does not cause any symptoms in and of itself. You should not rely on the information provided as a substitute for actual professional medical That means only one of your parents has to pass the genetic mutation on to you in order for you to inherit it. Your brothers and sisters may have inherited the mutated gene for Factor V Leiden, just like you did. The plan depends on exercise as much as diet. with these terms and conditions. Large amounts of garlic, ginger, glucosamine (an amino sugar), ginseng, and ginkgo should be avoided while on anticoagulant medications as they may increase the risk of bleeding. Limitations: You can eat anything you want on your weekly cheat day." Some issues that can be discussed with your doctor include: Other than the increased risk of developing DVT or PE, factor V Leiden may increase the risk of miscarriage or other pregnancy complications, such as preeclampsia and eclampsia, placental abruption (when the placenta separates too early from the wall of your uterus), and having a fetus that grows slower than is usual. Mayo Clinic does not endorse companies or products. However, you can reduce your risk of a deep vein thrombosis or pulmonary embolism if you: The majority of people who have the prothrombin gene mutation dont get a dangerous blood clot and the mutation doesnt cause deep vein thrombosis or pulmonary embolism in the vast majority of pregnancies. AskMayoExpert. Each part of the plan revolves around the number five. Your provider will advise you on whether you need testing, as well as on the pros and cons of testing. And it provides simple recipes that promise no more than 5 ingredients and 5 minutes of prep time. By continuing to browse this site you agree to our use of cookies. Cranberry juice and other cranberry products can alter the effects of anticoagulants. You inherit this condition from one of your biological parents. 1, 2 This Cardiology Patient Page will describe deficiencies in the natural anticoagulants, protein C, protein S, and antithrombin that may result in either 0000008077 00000 n You might have heard that "you can't choose your family," and the same applies to the genes you inherit from them. Its the most common blood clotting disorder thats inherited, or passed down within biological families. Leiden is the city in the Netherlands where researchers discovered the condition. small children have a risk of 1 in 100,000 per year, those in their twenties have a risk of 1 in 10,000 per year, by age 40, this risk is 1 in 1,000 per year. 9th ed. But theres no clear consensus, and researchers continue to explore what risks, if any, factor V Leiden poses during pregnancy. Foods to limit when you're following a heart-healthy diet include: 1. ", cdc.gov: "How much physical activity do adults need?". Advertising revenue supports our not-for-profit mission. Take your questions to your healthcare provider and get the answers you need. Vitamin K antagonists (VKAs) are the most commonly prescribed oral anticoagulants worldwide. If signs and symptoms do occur, they can include: Known as a pulmonary embolism, this occurs when a portion of a DVT breaks free and travels through the right side of your heart to your lung, where it blocks blood flow. .wpcdt-timer-24806 .wpcdt-clock .wpcdt-digits, Or ask someone to drive you to the nearest emergency room. When you are ready, talk with your health care provider for advice and help to lose weight. Vitamin K is necessary for making the proteins that aid in blood clotting, according to the Harvard T.H. https://www.uptodate.com/contents/search. This may not be a good choice for those who have to travel a lot for work, have an inflexible schedule, or prefer to eat out, as food prep and timing may be a problem. They were hot, red, and huge. If you develop a deep vein thrombosis or pulmonary embolism, your provider will prescribe an anticoagulant. Some hospitals do only the DNA test and not the screening test. Zoppi, Lois. Factor V Leiden. U.S. National Institutes of Health, National Library of Medicine. 0000003332 00000 n 0000000856 00000 n It is generally advised that patients taking anticoagulants keep to a balanced and consistent diet balanced throughout their treatment course to avoid fluctuations in treatment efficacy. 2. If you are homozygous, you will pass the mutation on to your children. Blood clots in less commonly affected veins, like those in your liver or brain. 4. Youre might be wondering, Will this happen to me?